Dick Storey
Hello Nova,
I like skepticism and caution. For me, both are an outcome of my upregulated biology genes. Drives my wife crazy. Among other things. 
A primary problem with individuals not getting vaccinated, if they are able to do that, is the potential for increased spread of the virus. And, of course, ending up sick enough to be hospitalized when the vaccine has been shown to help prevent that unfortunate, even dangerous consequence. But yes, of course the decision is yours to make.
Mice have been used in such studies for ages. Why? Mouse metabolism is quite similar to human--as strange as that sounds--and results have been shown to be reliable when extrapolated to humans. Mice are relatively easy to use in a study: They multiply like crazy, grow fast, are inexpensive to feed and maintain and require little space. Monkeys are probably better for trials but researchers catch hell for using them, from a number of legitimate angles, so labs shy away from simians. Rightly, I’d say.
Even small changes in the vaccine formula would indeed be better if tested on humans. But, the experts must have decided the pace of variant formation vs. the time human trials take, done properly, justifies the current strategy. At least that seems to be the case. Human trials are not without controversy on their own of course. For example, if you had a choice,would you want the placebo or the test material? How many subjects do you need in a trial to be statistically confident in the resulting data? How long do you run the trials--weeks, months, years? And so on.
Science is not just a collection of data and conclusions but, most importantly, is a process to generate good, reproducible data and sound conclusions that lead to more experiments/trials and revised, updated conclusions. The covid studies can serve as exhibit A but, as we all know, this process of medical science was often poorly understood by the press and caused anxiety and frustration, even fear, for many people. Scientists do upright, important work but all too often do not communicate effectively with the public.
To that: I'll bet you have heard enough from the science nerd in MT.
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